6/19/2023 0 Comments Thorium builder workshopPlans for the effort include producing greater quantities of the isotope-from the current 50–100 mCi per batch to 100–1,000 mCi per batch over the next 4 years. In 2019, the group announced routine production and product availability for purchase by end-users. Since its formation, the Tri-Lab Effort has distributed more than 275 mCi of accelerator-produced Ac-225 to evaluators. The goal of the Ac-225 Tri-Lab Effort is to leverage DOE IP facilities, capabilities, and expertise to fill the void in supply for the medical and research Ac-225 markets. After bombardment, the targets are removed and shipped to ORNL for chemical processing, and finally, the purified product is shipped to customers. Using accelerator beam facilities at Brookhaven and Los Alamos, thorium-232 targets are fabricated at the labs and placed into an accelerator. The Ac-225 Tri-Lab Effort was established in 2015 by the DOE IP and researchers at Brookhaven, Los Alamos, and Oak Ridge National Laboratories to research and develop new production routes for Ac-225. The Brookhaven Linac Isotope Producer (BLIP) One of these methods, accelerator-produced actinium-225, is being investigated by three national laboratories and was coined the Ac-225 Tri-Lab Effort. To address global demand and assist in providing this rare and critical isotope, the DOE IP organized facility usage and funding to research multiple routes for producing Ac-225. The demand for Ac-225 is growing daily with researchers, physicians, and patients around the world waiting for shipments of the radionuclide, which is then radiolabeled to yield individual patient doses. The process is repeated every month, with each batch yielding millicurie quantities of Ac-225. Scientists at Oak Ridge National Laboratory (ORNL) began "milking" the stores of Th-229-a process that involves separating Ac-225 from the other isotopes that decay from thorium. For many years, Th-229 was stored in a secure facility-until the discovery that Ac-225 and its decay daughter, Bi-213 were of great medical interest. Stores of Th-229 were considered a waste product, leftover from nuclear programs in the 1940s and 1950s. Presently, the primary source of Ac-225 comes from thorium-229 (Th-229) decay. Also of considerable interest in the medical community is the daughter isotope of Ac-225, bismuth-213 (Bi-213), which has applications as the radioactive component in cancer treatment options for leukemia, lymphomas, and micrometastatic carcinomas. Over the last 10+ years, the DOE IP has provided funding and facilities to aid in the research and development of new methods for creating the isotope. Department of Energy Isotope Program (DOE IP) identified Ac-225 as a critical isotope because of its high demand and limited availability. Many radiolabeled products that incorporate Ac-225 are currently being used in numerous clinical trials for the treatment of cancers including prostate cancer, myeloid leukemia, and breast cancer. Typically, the range is only that of a few cell diameters, making these isotopes highly effective at destroying cancer cells and leaving healthy cells untouched. Alpha-emitting isotopes show great promise for cancer treatment because of their short path length and high energy transfer of radiation. For this reason, the isotope is being evaluated as an ideal candidate for use in medical applications. Discovered in 1947 by a team at Argonne National Laboratory and an independent Canadian research team, actinium-225 (Ac-225) undergoes alpha decay to francium-221 with a half-life of 10 days.
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